Protective Efficacy of Recombinant Modified Vaccinia Virus Ankara Delivering Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein.
Identifieur interne : 001610 ( Main/Exploration ); précédent : 001609; suivant : 001611Protective Efficacy of Recombinant Modified Vaccinia Virus Ankara Delivering Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein.
Auteurs : Asisa Volz [Allemagne] ; Alexandra Kupke [Allemagne] ; Fei Song [Allemagne] ; Sylvia Jany [Allemagne] ; Robert Fux [Allemagne] ; Hosam Shams-Eldin [Allemagne] ; Jörg Schmidt [Allemagne] ; Christin Becker [Allemagne] ; Markus Eickmann [Allemagne] ; Stephan Becker [Allemagne] ; Gerd Sutter [Allemagne]Source :
- Journal of virology [ 1098-5514 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Anticorps neutralisants (immunologie), Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Glycoprotéine de spicule des coronavirus (immunologie), Glycoprotéine de spicule des coronavirus (métabolisme), Infections à coronavirus (), Lymphocytes T CD8+ (immunologie), Souris, Souris de lignée BALB C, Vaccins antiviraux (génétique), Vaccins antiviraux (immunologie), Virus de la vaccine (génétique), Évaluation préclinique de médicament ().
- MESH :
- génétique : Vaccins antiviraux, Virus de la vaccine.
- immunologie : Anticorps neutralisants, Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus, Lymphocytes T CD8+, Vaccins antiviraux.
- métabolisme : Glycoprotéine de spicule des coronavirus.
- Animaux, Infections à coronavirus, Souris, Souris de lignée BALB C, Évaluation préclinique de médicament.
English descriptors
- KwdEn :
- Animals, Antibodies, Neutralizing (immunology), CD8-Positive T-Lymphocytes (immunology), Coronavirus Infections (prevention & control), Drug Evaluation, Preclinical (methods), Mice, Mice, Inbred BALB C, Middle East Respiratory Syndrome Coronavirus (immunology), Spike Glycoprotein, Coronavirus (immunology), Spike Glycoprotein, Coronavirus (metabolism), Vaccinia virus (genetics), Viral Vaccines (genetics), Viral Vaccines (immunology).
- MESH :
- chemical , genetics : Viral Vaccines.
- chemical , immunology : Antibodies, Neutralizing, Spike Glycoprotein, Coronavirus, Viral Vaccines.
- genetics : Vaccinia virus.
- immunology : CD8-Positive T-Lymphocytes, Middle East Respiratory Syndrome Coronavirus.
- chemical , metabolism : Spike Glycoprotein, Coronavirus.
- methods : Drug Evaluation, Preclinical.
- prevention & control : Coronavirus Infections.
- Animals, Mice, Mice, Inbred BALB C.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory disease in humans. We tested a recombinant modified vaccinia virus Ankara (MVA) vaccine expressing full-length MERS-CoV spike (S) glycoprotein by immunizing BALB/c mice with either intramuscular or subcutaneous regimens. In all cases, MVA-MERS-S induced MERS-CoV-specific CD8(+) T cells and virus-neutralizing antibodies. Vaccinated mice were protected against MERS-CoV challenge infection after transduction with the human dipeptidyl peptidase 4 receptor. This MERS-CoV infection model demonstrates the safety and efficacy of the candidate vaccine.
DOI: 10.1128/JVI.00614-15
PubMed: 26018172
Affiliations:
- Allemagne
- Bavière, District de Giessen, District de Haute-Bavière, Hesse (Land)
- Marbourg, Munich
- Université Louis-et-Maximilien de Munich
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Le document en format XML
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sort="Jany, Sylvia" uniqKey="Jany S" first="Sylvia" last="Jany">Sylvia Jany</name><affiliation wicri:level="4"><nlm:affiliation>German Center for Infection Research (DZIF), Institute for Infectious Diseases and Zoonoses, LMU University of Munich, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Infection Research (DZIF), Institute for Infectious Diseases and Zoonoses, LMU University of Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Fux, Robert" sort="Fux, Robert" uniqKey="Fux R" first="Robert" last="Fux">Robert Fux</name><affiliation wicri:level="4"><nlm:affiliation>German Center for Infection Research (DZIF), Institute for Infectious Diseases and Zoonoses, LMU University of Munich, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Infection Research (DZIF), Institute for Infectious Diseases and Zoonoses, LMU University of Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Shams Eldin, Hosam" sort="Shams Eldin, Hosam" uniqKey="Shams Eldin H" first="Hosam" last="Shams-Eldin">Hosam Shams-Eldin</name><affiliation wicri:level="3"><nlm:affiliation>German Center for Infection Research (DZIF), Institute of Virology, Philipps University Marburg, Marburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Infection Research (DZIF), Institute of Virology, Philipps University Marburg, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Schmidt, Jorg" sort="Schmidt, Jorg" uniqKey="Schmidt J" first="Jörg" last="Schmidt">Jörg Schmidt</name><affiliation wicri:level="3"><nlm:affiliation>German Center for Infection Research (DZIF), Institute of Virology, Philipps University Marburg, Marburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Infection Research (DZIF), Institute of Virology, Philipps University Marburg, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Becker, Christin" sort="Becker, Christin" uniqKey="Becker C" first="Christin" last="Becker">Christin Becker</name><affiliation wicri:level="1"><nlm:affiliation>University of Giessen Lung Center, Department of Internal Medicine II, Section of Infectious Diseases, Giessen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Giessen Lung Center, Department of Internal Medicine II, Section of Infectious Diseases, Giessen</wicri:regionArea><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Eickmann, Markus" sort="Eickmann, Markus" uniqKey="Eickmann M" first="Markus" last="Eickmann">Markus Eickmann</name><affiliation wicri:level="3"><nlm:affiliation>German Center for Infection Research (DZIF), Institute of Virology, Philipps University Marburg, Marburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Infection Research (DZIF), Institute of Virology, Philipps University Marburg, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Becker, Stephan" sort="Becker, Stephan" uniqKey="Becker S" first="Stephan" last="Becker">Stephan Becker</name><affiliation wicri:level="3"><nlm:affiliation>German Center for Infection Research (DZIF), Institute of Virology, Philipps University Marburg, Marburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Infection Research (DZIF), Institute of Virology, Philipps University Marburg, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Sutter, Gerd" sort="Sutter, Gerd" uniqKey="Sutter G" first="Gerd" last="Sutter">Gerd Sutter</name><affiliation wicri:level="4"><nlm:affiliation>German Center for Infection Research (DZIF), Institute for Infectious Diseases and Zoonoses, LMU University of Munich, Munich, Germany gerd.sutter@lmu.de.</nlm:affiliation><country wicri:rule="url">Allemagne</country><wicri:regionArea>German Center for Infection Research (DZIF), Institute for Infectious Diseases and Zoonoses, LMU University of Munich, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author></analytic><series><title level="j">Journal of virology</title><idno type="eISSN">1098-5514</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Neutralizing (immunology)</term><term>CD8-Positive T-Lymphocytes (immunology)</term><term>Coronavirus Infections (prevention & control)</term><term>Drug Evaluation, Preclinical (methods)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Middle East Respiratory Syndrome Coronavirus (immunology)</term><term>Spike Glycoprotein, Coronavirus (immunology)</term><term>Spike Glycoprotein, Coronavirus (metabolism)</term><term>Vaccinia virus (genetics)</term><term>Viral Vaccines (genetics)</term><term>Viral Vaccines (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps neutralisants (immunologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie)</term><term>Glycoprotéine de spicule des coronavirus (immunologie)</term><term>Glycoprotéine de spicule des coronavirus (métabolisme)</term><term>Infections à coronavirus ()</term><term>Lymphocytes T CD8+ (immunologie)</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Vaccins antiviraux (génétique)</term><term>Vaccins antiviraux (immunologie)</term><term>Virus de la vaccine (génétique)</term><term>Évaluation préclinique de médicament ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Viral Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Neutralizing</term><term>Spike Glycoprotein, Coronavirus</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Vaccinia virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Vaccins antiviraux</term><term>Virus de la vaccine</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps neutralisants</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Glycoprotéine de spicule des coronavirus</term><term>Lymphocytes T CD8+</term><term>Vaccins antiviraux</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD8-Positive T-Lymphocytes</term><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Drug Evaluation, Preclinical</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Glycoprotéine de spicule des coronavirus</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Mice</term><term>Mice, Inbred BALB C</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Infections à coronavirus</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Évaluation préclinique de médicament</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory disease in humans. We tested a recombinant modified vaccinia virus Ankara (MVA) vaccine expressing full-length MERS-CoV spike (S) glycoprotein by immunizing BALB/c mice with either intramuscular or subcutaneous regimens. In all cases, MVA-MERS-S induced MERS-CoV-specific CD8(+) T cells and virus-neutralizing antibodies. Vaccinated mice were protected against MERS-CoV challenge infection after transduction with the human dipeptidyl peptidase 4 receptor. This MERS-CoV infection model demonstrates the safety and efficacy of the candidate vaccine. </div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bavière</li><li>District de Giessen</li><li>District de Haute-Bavière</li><li>Hesse (Land)</li></region><settlement><li>Marbourg</li><li>Munich</li></settlement><orgName><li>Université Louis-et-Maximilien de Munich</li></orgName></list><tree><country name="Allemagne"><region name="Bavière"><name sortKey="Volz, Asisa" sort="Volz, Asisa" uniqKey="Volz A" first="Asisa" last="Volz">Asisa Volz</name></region><name sortKey="Becker, Christin" sort="Becker, Christin" uniqKey="Becker C" first="Christin" last="Becker">Christin Becker</name><name sortKey="Becker, Stephan" sort="Becker, Stephan" uniqKey="Becker S" first="Stephan" last="Becker">Stephan Becker</name><name sortKey="Eickmann, Markus" sort="Eickmann, Markus" uniqKey="Eickmann M" first="Markus" last="Eickmann">Markus Eickmann</name><name sortKey="Fux, Robert" sort="Fux, Robert" uniqKey="Fux R" first="Robert" last="Fux">Robert Fux</name><name sortKey="Jany, Sylvia" sort="Jany, Sylvia" uniqKey="Jany S" first="Sylvia" last="Jany">Sylvia Jany</name><name sortKey="Kupke, Alexandra" sort="Kupke, Alexandra" uniqKey="Kupke A" first="Alexandra" last="Kupke">Alexandra Kupke</name><name sortKey="Schmidt, Jorg" sort="Schmidt, Jorg" uniqKey="Schmidt J" first="Jörg" last="Schmidt">Jörg Schmidt</name><name sortKey="Shams Eldin, Hosam" sort="Shams Eldin, Hosam" uniqKey="Shams Eldin H" first="Hosam" last="Shams-Eldin">Hosam Shams-Eldin</name><name sortKey="Song, Fei" sort="Song, Fei" uniqKey="Song F" first="Fei" last="Song">Fei Song</name><name sortKey="Sutter, Gerd" sort="Sutter, Gerd" uniqKey="Sutter G" first="Gerd" last="Sutter">Gerd Sutter</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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